Investigation of Associations between NR1D1, RORA and RORB Genes and Bipolar Disorder
نویسندگان
چکیده
منابع مشابه
Investigation of Associations between NR1D1, RORA and RORB Genes and Bipolar Disorder
Several genes that are involved in the regulation of circadian rhythms are implicated in the susceptibility to bipolar disorder (BD). The current study aimed to investigate the relationships between genetic variants in NR1D1 RORA, and RORB genes and BD in the Han Chinese population. We conducted a case-control genetic association study with two samples of BD patients and healthy controls. Sampl...
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چکیده ندارد.
Evidence for genetic association of RORB with bipolar disorder
BACKGROUND Bipolar disorder, particularly in children, is characterized by rapid cycling and switching, making circadian clock genes plausible molecular underpinnings for bipolar disorder. We previously reported work establishing mice lacking the clock gene D-box binding protein (DBP) as a stress-reactive genetic animal model of bipolar disorder. Microarray studies revealed that expression of t...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0121245